Journal article
Impact of prehospital opioid dose on angiographic and clinical outcomes in acute coronary syndromes
H Fernando, Z Nehme, D Dinh, E Andrew, A Brennan, W Shi, J Bloom, SJ Duffy, J Shaw, K Peter, V Nadurata, W Chan, J Layland, M Freeman, W Van Gaal, S Bernard, J Lefkovits, D Liew, M Stephenson, K Smith Show all
Emergency Medicine Journal | BMJ PUBLISHING GROUP | Published : 2022
Abstract
Background An adverse interaction whereby opioids impair and delay the gastrointestinal absorption of oral P2Y 12 inhibitors has been established, however the clinical significance of this in acute coronary syndrome (ACS) is uncertain. We sought to characterise the relationship between prehospital opioid dose and clinical outcomes in patients with ACS. Methods Patients given opioid treatment by emergency medical services (EMS) with ACS who underwent percutaneous coronary intervention (PCI) between 1 January 2014 and 31 December 2018 were included in this retrospective cohort analysis using data linkage between the Ambulance Victoria, Victorian Cardiac Outcomes Registry and Melbourne Interven..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
SJD's work is supported by a National Health and Medical Research Council (NHMRC) of Australia grant (No. 1111170). DS is supported by a National Heart Foundation of Australia Future Leader Fellowship (reference no. 101908). ZN is supported by a NHMRC Early Career Fellowship (reference no. 1146809).